Simulation snapshot of a DPPC bilayer containing a single cholesterol molecule, showcasing a phospholipid whose headgroup is oriented toward the cholesterol. It thereby shields the latter from contact with water, shown as the smooth isodensity surface in the background. Hydrogen atoms are omitted for clarity. Highlighted are the oxygen atom of cholesterol, the phosphate and nitrogen atoms in the DPPC headgroup, and the three carbon atoms used in the Voronoi tessellation for the phospholipid. To see this figure in color, go online.