Figure 6.

Example demonstrating the results of control, EDC, and ODC after E-4031 addition. An example cell (cell 13, Fig. 7) showing the effects of adding I_target while paced at 0.5 Hz is shown. The gray (A and D), orange (B, D, and E), and green (C–E) traces represent the control without any current addition, adding I_target with EDC, and adding I_target with ODC, respectively. (A–C) The darker traces represent the stimulated APs after E-4031 addition, whereas the light-colored traces represent the stimulated APs before E-4031 addition. (D) Overlays of AP traces from the three conditions after E-4031 addition are shown. (E) Calculated target currents for EDC and ODC are shown. Black triangles indicate when a stimulus current was delivered and provide a reference to which of the 10 paced APs in Fig. S9 are displayed. The time axis corresponds to the time within the full recording shown in Fig. S9.