Fig. 1.

Screenshot of DEPO portal. Example showing a search for drug therapies pertaining to the BRAF gene in skin cutaneous melanoma (SKCM). JSmol provides visualization of protein residue locations with known drug activity as reported in the DEPO database (blue) and of the query site (yellow), which HotSpot3D has predicted to be putative candidate site with functional significance. The table below lists the curated drug information for the mutationally clustered sites (blue), i.e. drug therapy, drug class, evidence level, drug effect and hyperlinks to literature sources