Table 1.

Epigenetic and behavioral deficits found in schizophrenia patients and in PRS mice.

Schizophrenia	PRS mice
+ Positive (stereotype behaviors)	+ stereotype behaviors
+ Negative (SI deficits) symptoms	+ SI deficits symptoms
+ sensitivity to NMDAR blockers	+ sensitivity to NMDAR blockers
+ cognitive symptoms	+ information processing deficit (PPI, fear conditioning)
Reduction of the GAD67, RELN, BDNF expression levels	Reduction of the GAD67, RELN, BDNF expression levels in frontal cortex
Increase of DNMT1, 3A and TET1 expression levels	Increase of DNMT1, 3A and TET1 expression levels in frontal cortex
Increase in 5MC and 5HMC enrichment at Gadl, Reln and Bdnf promoters	Increase in 5MC and 5HMC enrichment at Gadl, Reln and Bdnf promoters

(+): presence. Abbreviations: BDNF, brain-derived neurotrophic factor; DNMT1, DNA-methyltransferase 1; TET1, ten-eleven methylcytosine dioxygenase 1; SI, social interaction, NMDA, N-methyl D-aspartate; PPI, pre-pulse inhibition; GAD67, glutamic acid decarboxylate; 5HMC, 5-hydroxymethylcytosine; 5MC, 5methylcytosine