Table 2.

Comparison of epigenetic and behavioral abnormalities induced by mGlu2/3 receptors agonist LY379268 and clozapine in PRS mice.

Clozapine	LY379268
Increase in Gadd45-β expression	Increase in Gadd45-β expression
Reduction of the overexpression of DNMT1 and TET1 in frontal cortex	Reduction of the overexpression of DNMT1 and TET1 in frontal cortex
Reduction of Gad1, Reln, and Bdnf promoter hypermethylation and increase in their mRNA levels	Reduction of the MeCP2 binding at the mGlu2, Gad1, Bdnf gene promoters
Reversal effects of the binding of DNMT1 to unmethylated target promoters	Reversal effects of the binding of MeCP2 to unmethylated target promoters
Reduction in locomotor hyperactivity and deficits in SI	Reduction in locomotor hyperactivity and deficits in SI

BDNF, brain-derived neurotrophic factor; DNMT1, DNA-methyltransferase 1; TET1, ten-eleven methylcytosine dioxygenase 1. Gadd45 (Growth – arrest and DNA damage; MeCP2, Methylcytosine binding protein 2.