Table 2.
Release exponent (n), rate constant (k), and correlation coefficient (R2) for the two drug-loaded micelles
Samples | Time interval (hours) | pH=7.4 | pH=5.0 | pH=5.0+10 mM GSH | ||||||
---|---|---|---|---|---|---|---|---|---|---|
n | k | R2 | n | k | R2 | n | k | R2 | ||
mPEG-4sPLMBz | 0–2 | 0.526 | 0.135 | 0.991 | 0.693 | 0.140 | 0.999 | – | – | – |
3–12 | 0.251 | 0.186 | 0.987 | 0.347 | 0.196 | 0.985 | – | – | – | |
24–72 | 0.148 | 0.235 | 0.990 | 0.160 | 0.311 | 0.996 | – | – | – | |
RGD-PEG-ss- 4sPLMBz | 0–2 | 0.789 | 0.169 | 0.993 | 0.756 | 0.225 | 0.995 | 0.639 | 0.285 | 0.993 |
3–12 | 0.215 | 0.282 | 0.953 | 0.219 | 0.367 | 0.973 | 0.215 | 0.417 | 0.966 | |
24–72 | 0.009 | 0.480 | 0.999 | 0.088 | 0.500 | 0.988 | 0.082 | 0.568 | 0.953 |
Abbreviations: GSH, glutathione; mPEG, methoxy poly(ethylene glycol); PEG, poly(ethylene glycol).