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Basal in vivo thymus mutation spectra in control, humanised and heterozygous NBS mice. Mutations were determined by DNA sequencing of plasmids rescued from the thymus of mice carrying the lacZ reporter as in the experiments shown in Fig. 3. (A) Control mice (Nbn+/+) and humanised mice (Nbn−/−NBNdel5). (B) Heterozygous Nbn+/− mice. The legend gives the four types of mutation detected.
