Table 1.

List of differentially expressed proteins after berberine8998 treatment in hamsters. The proteins were identified by TOF-AB 5600 (↑, upregulated; ↓, down-regulated).

Protein name	Gene name	P-value	Fold of change	Protein function
Peroxisomal carnitine O-octanoyl transferase	Crot	1.57×10−5	0.69↓	Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate.
Alpha-N-acetyl galactosaminidase	Naga	3.58×10−5	1.71↑	Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides.
Heterogeneous nuclear ribonucleoprotein K	Hnrnpk	4.13×10−5	0.67↓	One of the major pre-mRNA-binding proteins.
Peroxisomal acylcoenzyme A oxidase 1	Acox1	1.24×10−3	0.52↓	Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.
Acetyl-CoA acetyltransferase	Acta2	1.28×10−3	1.55↑	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Apolipoprotein B-100	Apob	1.45×10−3	0.75↓	Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100).
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1	Plcd1	1.58×10−3	1.37↑	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Guanine nucleotide binding protein subunit beta-2-like 1	Gnb2l1	2.16×10−3	0.69↓	Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules.
Uricase	Uox	2.34×10−3	0.54↓	Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
40S ribosomal protein S15	Rps15	2.50×10−3	0.52↓	Liver regeneration. Ribosomal small subunit assembly.
Long-chain-fatty-acid—CoA ligase 1	ACSL1	2.10×10−3	0.50↓	Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses oleate, arachidonate, eicosapentaenoate and docosahexaenoate as substrates.