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. 2018 Apr 12;39(9):1473–1482. doi: 10.1038/aps.2017.200

Table 4.

Pharmacokinetic parameters of berberine and berberine8998 in hamsters.

Drug Dose (mg) T max (h) C max (ng/mL) AUClast (h*ng/mL) AUCinf (h*ng/mL)
Berberine 50 0.5±0.3 42.3±6.6 125.6±48.1 119.7±118.5
Berberine8998 50 0.6±0.2 126.9±47.2 457.2±132.9 601.7±625.4