Figure 7.

Increased susceptibility to BON by depleting cellular GSH. (A) A549 cells were treated with different concentrations of BSO for 48 h, and cell viability was detected by MTT assay. The data are presented as the mean±SD. (B) The intracellular GSH levels in the BSO-treated cells were measured by a GSH assay kit. The A549 cells were pretreated with BSO for 24 h and then treated with BON (C) or DDP (D) for 48 h and detected by MTT assay. The results are expressed as the mean±SD from three separate experiments. ^* P<0.05, ^** P<0.01.