Fig. 6.

HBXIP accelerates the tumor growth through suppressing miR-18b and enhancing the interaction between MDM2 and p53 in mice. a Growth curve of tumors in nude mice. b Average weight of tumors. c Tumor images. d The relative expression levels of HBXIP, MDM2, and p53 in the tumor tissues from mice were detected by Western blot analysis. The data presented are from three independent experiments; Student’s t test; *P < 0.05; **P < 0.01