Table 1.
The IC50 and EC50 value of main ingredients from DBT.
| Order | Compounds | IC50 | EC50 |
|---|---|---|---|
| 1 | Crocin I | >1000 | >1000 |
| 2 | Crocin II | >1000 | >1000 |
| 3 | Hydroxysafflor Yellow A | >1000 | >1000 |
| 4 | Gentiopicrin | >1000 | >1000 |
| 5 | Adenosine | >1000 | 777.91±212.3 |
| 6 | Rutin | >1000 | >1000 |
| 7 | Swertiamain | >1000 | >1000 |
| 8 | Sweroside | >1000 | >1000 |
| 9 | Astragaioside I | >1000 | >1000 |
| 10 | Astragaloside I (A) | >1000 | 269.05±54.7 |
| 11 | Ononin | >1000 | >1000 |
| 12 | Calycosin (C) | 149.93±16.9 | 137.92±27.1 |
| 13 | Ferulaic Acid | >1000 | >1000 |
| 14 | Levistilide A (L) | 30.82±12.2 | 6.62±4.3 |
| Ctrl | Sorafenib | 6.93±1.2 | 7.68±1.9 |
| Ctrl | sb431542 | 70.25±10.32 | 13.88±4.21 |
1-14, main ingredients from DBT; sorafenib and sb431542, set as positive control. IC50, 50% growth inhibition on normal LX-2 cells; EC50, 50% growth inhibition on LX-2 cells activated by 10 ng/mL TGF-β1.