Fig. 4.

In vivo efficacy of Ec-LDP-hBD1. Experiment 1 (Exp 1), athymic mice bearing human epidermoid carcinoma A431 xenografts were treated with LDP, Ec-LDP, and Ec-LDP-hBD1 intravenously at different doses (n = 6). Mean tumor volumes (a) and mean body weights (b) of mice in each group are shown. Arrows, the day of injection (days 10 and 18). Experiment 2 (Exp 2), athymic mice bearing H460 xenografts. Mean tumor volumes (c) and mean body weights (d) of mice in each group are shown. Arrows, the day of injection (days 7 and 16). *P < 0.05, #P < 0.05