Fig. 1.

Effects of Mtr on body weight gain, visceral adiposity, hepatosteatosis and glucose tolerance in HFru-fed mice. Mice were fed a high-fructose (HFru) diet for 8 weeks and matrine (Mtr, 100 mg/kg per day in diet) was administered in the last 4 weeks. A glucose tolerance test (GTT at 3 g glucose/kg BW, ip) was conducted after 2 weeks of treatment with Mtr. Epididymal (Epi) fat weight and liver TG content were determined at the end of the study. (a) Body weight gain, (b) Epididymal fat weight as a percentage of body weight, (c) Caloric intake, (d) TG content in liver and muscle. (e) Glucose tolerance. **P < 0.01 vs CH; ^#P < 0.05, ^##P < 0.01 vs HFru (n = 7–8 mice/group)