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. 2018 May 10;39(9):1513–1521. doi: 10.1038/aps.2017.184

Figure 6.

Figure 6

AT1R knockdown blocks SND p102-induced ECM production and cell proliferation in cultured MCs. A 50 nmol/L aliquot of AT1R siRNA or control siRNA and 1 μg of pcDNA3.0-SND p102 plasmid or pcDNA3.0 plasmid were cotransfected into cells for 48 h. AT1R, fibronectin, collagen IV, and TGF-β protein levels were measured by Western blot analysis (A). Cell proliferation was measured by BrdU incorporation assay (B). Data represent the mean±SEM of at least 3 experiments. * P<0.05, ** P<0.01 compared with pcDNA3.0 plasmid- and control siRNA-transfected samples. ## P<0.01 compared with pcDNA3.0-SND p102 plasmid- and control siRNA-transfected samples.