Figure 4.

High ratios of COX-2-immunopositive neurons/total neurons are exclusively found in severely damaged cortical and hippocampal regions. (A) In the cortical regions of the normoxic time control group (n=7), the neuropathology scores were typically low and associated with low levels of COX-2-immunopositive neurons. Similar observations were made for the 20-min asphyxia+H₂ group (n=7) as well. However, in the 20-min asphyxia group (n=7), severe neuronal lesions may or may not be associated with high percentages of COX-2-immunopositive neurons. Importantly, high COX-2 immunopositivity was not associated with low neuropathology scores in any animals/regions. (B) In the hippocampal CA3 subfield, the highest number COX-2-immunopositive neurons was from the 20-min asphyxia group with largest degree of neuronal damage.