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Hit validation and analysis of the mechanism of action of the derivative DCSM06-05. (A) Inhibitory activities of DCSM06-05. (B) SPR assay demonstrated binding between SMARCA2-BRD and DCSM06-05. (C) Molecular docking analysis elucidated key interactions with SMARCA2-BRD. (D) Schematic diagram showing interactions between SMARCA2-BRD and DCSM06-05. Hydrogen bonds are shown in green dashed lines, and residues involved in these interactions were illustrated in the LigPlot+ program33.
