Figure 1.

Human miRNAs involved in cardiovascular diseases (CVDs) and their presence in biological fluids. Panel A, human chromosomal ideogram depicting the genomic location of key miRNAs loci and their involvement in CVDs obtained from HMDD 2.0 database¹⁸ (Supplementary Table S1 for more details) and generated by the Phenogram web application (http://visualization.ritchielab.psu.edu/phenograms/plot). Panel B, word-cloud representation of the different human miRNAs showing experimental evidence of involvement in CVDs and generated by the Wordart web application (http://wordart.com). The size of miRNA names is proportional to the number of PUBMED references demonstrating their functional involvement at the cellular or organ level in CVDs. Panel C, Venn diagram showing the presence of miRNAs involved in CVDs that can be also detected in plasma/serum, urine and saliva as compiled in miRandola 2017 database for circulating miRNAs¹¹⁶ and generated by the DrawVenn application (http://bioinformatics.psb.ugent.be/webtools/Venn). For clarity reasons, miRNA nomenclature from miRBase 21.0 has been abbreviated by removing the specific human (hsa) prefix.