Table 3.

Mean pharmacokinetic parameters of Lv and LvA in intestine

	Lv			LvA
Parameters	Control+Lv	HFD+Lv	HFD+XZK	Control+Lv	HFD+Lv	HFD+XZK
Tmax (h)	2.00	2.00	2.00	2.00	2.00	2.00
Cmax (ng/mg)	12.47	16.47	23.98	4.41	2.60	5.67
AUC0−t (h*ng/mg)	29.45	40.45	47.23	13.66	6.47	18.25
AUC0−∞ (h*ng/mg)	29.50	40.50	47.25	16.47	6.86	25.21
t1/2 (h)	0.44	0.42	0.35	1.64	0.98	2.21
Conversion ratio (Lv to LvA, %)	34.8	13.9	33.8

The experimental groups were as follows: Lv administration (10 mg/kg, i.g.) in the control mice (Control + Lv), Lv administration (10 mg/kg, i.g.) in the HFD mice (HFD + Lv), XZK administration (1200 mg/kg, i.g., an equivalent dose to 10 mg/kg of Lv) in the HFD mice (HFD + XZK). n = 6

T_max time to peak concentration, C_max peak concentration, AUC_0–t, area under the concentration–time curve from zero to the time of last measurable concentration, AUC_0−∞ area under the concentration–time curve from zero to infinity, t_1/2 apparent elimination half-time