Table 5.

Mean pharmacokinetic parameters of Lv and LvA in muscle

	Lv			LvA
Parameters	Control+Lv	HFD+Lv	HFD+XZK	Control+Lv	HFD+Lv	HFD+XZK
Tmax (h)	2.00	2.00	2.00	2.00	2.00	2.00
Cmax (ng/mg)	0.33	0.70	0.41	0.55	0.36	0.70
AUC0−t (h*ng/mg)	0.76	1.71	0.81	1.29	1.13	1.68
AUC0−∞ (h*ng/mg)	0.79	1.82	0.84	1.32	1.32	1.74
t1/2 (h)	0.80	0.96	0.75	0.74	1.48	0.79
Conversion ratio (Lv to LvA, %)	61.6	41.0	66.6

The experimental groups were as follows: Lv administration (10 mg/kg, i.g.) in the control mice (Control + Lv), Lv administration (10 mg/kg, i.g.) in the HFD mice (HFD + Lv), XZK administration (1200 mg/kg, i.g., an equivalent dose to 10 mg/kg of Lv) in the HFD mice (HFD + XZK). n = 6

T_max time to peak concentration, C_max peak concentration, AUC_0–t area under the concentration–time curve from zero to the time of last measurable concentration, AUC_0−∞ area under the concentration–time curve from zero to infinity, t_1/2 apparent elimination half-time