Table 1.
Effect of 3Ac-OA on food consumption, body weight, liver weight and serum biochemical parameters in HFD rats. Data are expressed as the mean±SD. * P<0.05, ** P<0.01 compared with control group. # P<0.05, ## P<0.01 compared with HFD group.
| Parameters | Vehicle | HFD | Atorvastatin (5 mg/kg) | 3Ac-OA (60 mg/kg) | 3Ac-OA (30 mg/kg) | 3Ac-OA (15 mg/kg) |
|---|---|---|---|---|---|---|
| Weight gain (g) | 70.8±5.2 | 56.6±7.1** | 43.1±13.2 | 45.3±17.4 | 52.9±7.2 | 55.1±8.2 |
| Food intake (g/day/rat) | 21.0±4.1 | 15.3±4.2** | 15.8±3.4 | 14.6±3.8 | 17.5±4.6 | 19.3±2.9 |
| Serum lipid (mmol/L) | ||||||
| TG | 1.33±0.40 | 3.93±1.06** | 3.41±0.71 | 2.21±0.54# | 2.83±0.56 | 2.95±0.48 |
| TC | 2.88±0.29 | 4.29±1.16** | 2.42±0.94## | 2.54±1.16# | 2.98±1.28# | 3.35±1.07 |
| HDL-C | 2.03±0.07 | 2.96±0.96* | 2.33±0.37 | 2.32±0.43 | 2.06±0.29 | 1.98±0.54 |
| LDL-C | 0.83±0.19 | 2.36±0.45** | 1.87±0.36# | 1.35±0.53## | 1.51±0.24# | 1.98±0.86 |
| Liver changes | ||||||
| Liver weight (g) | 8.52±0.59 | 12.48±2.25** | 11.02±1.21 | 10.92±1.05 | 11.95±1.45 | 12.06±1.53 |
| Liver index | 0.021±0.001 | 0.033±0.006** | 0.031±0.002 | 0.029±0.001 | 0.030±0.002 | 0.032±0.002 |
| Liver TG (mg/mg) | 2.15±0.65 | 10.26±5.67** | 5.14±1.07 | 3.75±0.92# | 7.40±1.32 | 8.95±1.44 |
| Liver TC (mg/mg) | 3.41±0.33 | 13.83±4.99** | 8.31±1.93 | 6.79±2.09# | 7.42±2.09 | 9.06±2.01 |