Figure 1.

Synergistic antitumor activity of apatinib with docetaxel in A549 xenografts. (A) Tumor size. The picture was taken on day 21 after treatment. (B) Mean tumor volume on different days. The detailed dosing regimen is shown with red dots with green triangles at the bottom. (C) Inhibitory rate of tumor growth. (D) Body weight on different days. The various administrations were as follows: vehicle (vehicle alone); apatinib (100 mg/kg, every day for 20 days); docetaxel (8 mg/kg, every four days for five times); apatinib (100 mg/kg) plus docetaxel (8 mg/kg, every four days for five times). ^* P<0.05, ^** P<0.01 vs vehicle. ^# P<0.05, ^## P<0.01, apatinib+docetaxel vs docetaxel or apatinib.