Figure 4.

Effects of docetaxel with or without apatinib on efflux transporters. Gene expression levels of efflux transporters in the tumor (A) and intestine (C). Protein levels of P-gp in the tumor (B) and intestine (D). The various administrations were as follows: vehicle (vehicle alone); apatinib (100 mg/kg, every day for 20 days); docetaxel (8 mg/kg, every four days for five times); apatinib (100 mg/kg) plus docetaxel (8 mg/kg, every four days for five times). ^** P<0.01 vs vehicle. ^## P<0.01, apatinib+docetaxel vs docetaxel.