Skip to main content
. 2018 Nov 5;3(11):14814–14823. doi: 10.1021/acsomega.8b02254

Figure 2.

Figure 2

GIRK1/2-dependent DMR response to ML297 can be diminished using known GIRK channel inhibitors. (a,c,e) Exemplary DMR traces of ML297-stimulated HEK cells stably expressing GIRK1/2 channels after preincubation with indicated concentrations of ionic barium, SCH, or TPNQ. (b,d,f) Concentration-effect relationships calculated from AUC of DMR recordings (n = 3) (a,c,e), between 0–4800 (a), 300–3900 (c), and 0–8000 s (e). For pEC50 values, see Table S2. (g–i) AUC quantification of DMR traces of PGE1 (100 μM) and ATP (100 μM) (n = 2), calculated between 0–4800 (g), 300–3900 (h), and 0–8000 s (i).