Table 1. Results of a representative KEGG database and literature search.
| Metabolic pathway | Related metabolites | Related disease | |||
|---|---|---|---|---|---|
| KEGG ID | Pathway | KEGG ID | KEGG Compound | KEGG ID | KEGG Disease / Disease-Related References |
| map00230 | Purine metabolism | C00385 | Xanthine | H00674 | Anemia due to disorders of nucleotide metabolism |
| C00262 | Hypoxanthine | H00824 | Calcification of joints and arteries | ||
| map00240 | Pyrimidine metabolism | C00112 | CDP (cytidine diphosphate) | H00674 | Anemia due to disorders of nucleotide metabolism |
| C00063 | CTP (cytidine triphosphate) | H00824 | Calcification of joints and arteries | ||
| map04152 0 | AMPK signaling pathway | C00020 | AMP (adenosine monophosphate) |
- | Regulation of cell metabolism in cardiometabolic diseases (atherosclerosis, heart failure, diabetes) [29] |
| map00340 | Histidine metabolism* | C00386 | Carnosine | - | Cholesterol and glucose metabolism (diabetic nephropathy) [30, 31] |
The first main column (with two sub-columns) represents metabolic pathways, the second main column shows metabolites important for the respective pathway and the third main column depicts disease entries linked to the respective metabolic pathway.
* interacting with the purine metabolism.