Table 1.

Strategies of targeting cellular senescence.

Strategy	Approach		Example	Ref
Elimination of senescent cells	Apoptosis inducer		ABT-263, dasatinib	51, 52, 53, 54
	Immune system-mediated	Specific antibody	CD44 antibody	55
	clearance	Specific antibody with cytotoxic agent	DPP4 antibody coupled to cytotoxicity	56
SASP attenuation	Targeting SASP induction	NF-κB inhibitors	Glucocorticoids, metformin	57
		mTOR inhibitors	Rapamycin	42
	Blocking activity of SASP	Inhibitors of secretory factors	Anti-IL-6 receptor antibody, IL-6 inhibitor	58