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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Curr Opin Endocr Metab Res. 2018 Apr 24;1:19–24. doi: 10.1016/j.coemr.2018.04.002

Figure 1.

Figure 1

An approach to screening in familial pituitary adenomas. Index cases or individuals with syndromic features should be offered targeted genetic testing for the syndrome in question. Index cases or individuals with negative targeted sequencing or those without a defined syndrome should be offered whole exome or genome sequencing. Screening should also be offered to a first-degree relative when a germline mutation has been identified. Additionally, the identification of a germline mutation should prompt periodic clinical, biochemical and radiological screening for the syndrome in question.