Table 2. Relationship between thyroid hormone profile and platelet count and mean platelet volume.
TSH: thyroid stimulating hormone; T4: L-thyroxine; T3: 3, 3′, 5-L-triiodothyronine; CI: confidence interval; REF: reference quartile
| Platelet Count (103 platelets/uL) | Mean Platelet Volume (attoliters) | |||||||
| Unadjusted | Adjusted | Unadjusted | Adjusted | |||||
| Mean difference (95% CI) | P-value | Mean difference (95% CI) | P-value | Mean difference (95% CI) | P-value | Mean difference (95% CI) | P-value | |
| TSH (uIU/mL) | ||||||||
| TSH | -3.35 (-5.45 to -1.26) | 0.002 | -2.09 (-4.29 to 0.11) | 0.06 | -3.48 (-35.69 to 28.72) | 0.83 | 12.28 (-21.8 to 46.36) | 0.47 |
| TSH Q1 | REF | REF | REF | REF | ||||
| TSH Q2 | -6.31 (-12 to -0.62) | 0.03 | -4.97 (-11.05 to 1.11) | 0.11 | 55.01 (-24.68 to 134.7) | 0.17 | 92.21 (-1.2 to 185.62) | 0.05 |
| TSH Q3 | -6.27 (-11.35 to -1.19) | 0.02 | -6.66 (-12.37 to -0.94) | 0.02 | 99.53 (30.36 to 168.69) | 0.005 | 103.72 (24.62 to 182.82) | 0.01 |
| TSH Q4 | -8.09 (-13.6 to -2.59) | 0.004 | -5.83 (-10.92 to -0.73) | 0.03 | -5 (-84.23 to 74.24) | 0.90 | 49.73 (-30.38 to 129.85) | 0.22 |
| Serum T4 (ug/mL) | ||||||||
| T4 | 4.09 (2.9 to 5.27) | <0.001 | 2.03 (0.7 to 3.36) | 0.003 | 28.12 (9.67 to 46.56) | 0.003 | 30.92 (6.44 to 55.39) | 0.01 |
| T4 Q1 | REF | REF | REF | REF | ||||
| T4 Q2 | 4.6 (0.11 to 9.08) | 0.04 | 2.07 (-2.53 to 6.67) | 0.37 | 39.38 (-32.76 to 111.52) | 0.28 | 34.31 (-57.51 to 126.14) | 0.46 |
| T4 Q3 | 9.88 (5 to 14.76) | <0.001 | 4.07 (-1.06 to 9.21) | 0.12 | 47.76 (-34.24 to 129.75) | 0.25 | 74.23 (-25.29 to 173.75) | 0.14 |
| T4 Q4 | 15.65 (10.5 to 20.79) | <0.001 | 7.83 (1.84 to 13.82) | 0.01 | 102.38 (28.49 to 176.28) | 0.007 | 109.64 (1.1 to 218.18) | 0.05 |
| Serum Free T4 (ng/dL) | ||||||||
| Free T4 | -27.84 (-47.27 to -8.42) | 0.006 | -18.87 (-39.39 to 1.65) | 0.07 | 544.08 (191.9 to 896.26) | 0.003 | 534.48 (151.85 to 917.11) | 0.007 |
| Free T4 Q1 | REF | REF | REF | REF | ||||
| Free T4 Q2 | -5.79 (-10.64 to -0.94) | 0.02 | -4.53 (-9.97 to 0.92) | 0.10 | 107.78 (22.24 to 193.32) | 0.01 | 89.94 (-12.01 to 191.9) | 0.08 |
| Free T4 Q3 | -17.5 (-24.58 to -10.42) | <0.001 | -15.64 (-24.06 to -7.23) | <0.001 | 282.47 (144.1 to 420.84) | <0.001 | 236.22 (90.14 to 382.3) | 0.002 |
| Free T4 Q4 | -7.17 (-12.85 to -1.49) | 0.01 | -4.95 (-11.13 to 1.24) | 0.11 | 123.59 (29.05 to 218.12) | 0.01 | 124.42 (24.06 to 224.78) | 0.02 |
| Serum T3 (ng/dL) | ||||||||
| T3 | 0.09 (-0.02 to 0.19) | 0.09 | -0.05 (-0.17 to 0.07) | 0.38 | 2.85 (1.16 to 4.54) | 0.001 | 2.66 (0.65 to 4.66) | 0.01 |
| T3 Q1 | REF | REF | REF | REF | ||||
| T3 Q2 | 4.35 (-1.55 to 10.25) | 0.14 | -0.53 (-6.72 to 5.67) | 0.86 | 125.58 (40.97 to 210.19) | 0.004 | 123.63 (16.77 to 230.49) | 0.02 |
| T3 Q3 | 5.03 (-1.52 to 11.58) | 0.13 | 0.46 (-6.7 to 7.62) | 0.90 | 58.5 (-46.67 to 163.67) | 0.27 | 68.68 (-40.84 to 178.19) | 0.21 |
| T3 Q4 | 4.33 (-2.74 to 11.39) | 0.22 | -3.16 (-10.89 to 4.56) | 0.41 | 176.63 (71.4 to 281.86) | 0.001 | 160.25 (36.39 to 284.11) | 0.01 |
| Serum Free T3 (pg/mL) | ||||||||
| Free T3 | 6.84 (0.8 to 12.88) | 0.03 | 4.32 (-3.71 to 12.36) | 0.28 | 61.5 (-55.48 to 178.48) | 0.30 | 6.03 (-105.51 to 117.56) | 0.91 |
| Free T3 Q1 | REF | REF | REF | REF | ||||
| Free T3 Q2 | -0.16 (-6.76 to 6.44) | 0.96 | -1.35 (-9.03 to 6.33) | 0.73 | 121.5 (37.24 to 205.75) | 0.006 | 116.67 (-0.22 to 233.56) | 0.05 |
| Free T3 Q3 | 2.31 (-4.48 to 9.09) | 0.50 | 1.88 (-5.98 to 9.73) | 0.63 | 290.15 (139.43 to 440.87) | <0.001 | 118.17 (12.21 to 224.13) | 0.03 |
| Free T3 Q4 | 4.04 (-1.96 to 10.03) | 0.18 | 0.79 (-7.07 to 8.66) | 0.84 | 131.44 (39.53 to 223.35) | 0.006 | 56 (-60.14 to 172.14) | 0.34 |