Table 5. Sub-strains generated from AD monomer isolated by SEC or cutoff filter.
Tau monomer (Ms) from AD brain was purified by immunoprecipitation followed by SEC or passage through a 100kD cutoff filter, prior to inoculation into DS1 cells. Columns indicate the number of clones identified (n) and the percentage this represents of the total (%). A single AD sub-strain was identified regardless of purification method. Classification of cell morphology was performed using blinded analysis.
| Ms | SEC | 100kD filter | ||
|---|---|---|---|---|
| N | % | N | % | |
| AD(m) | 47 | 100 | 23 | 100 |