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. 2018 Dec 11;7:e42298. doi: 10.7554/eLife.42298

Figure 4. LATS2 antagonizes formation of the apical domain (A) In embryos at 16–32 cell stages, PARD6B is detectable in GFP-overexpressing and in non-injected cells, but not in Lats2-overexpressing cells (arrowheads, n = embryos).

Figure 4.

(B) At 16–32 cell stages, aPKCz is detectable in GFP-overexpressing and in non-injected cells, but not in Lats2-overexpressing cells (arrowheads, n = embryos). (C) Quantification of embryos shown in panel A (p, student’s t-test). (D) Quantification of embryos shown in panel B (p, student’s t-test). (E) At 16–32 cell stages, CDH1 is localized to the basolateral membrane in both Lats2-overexpressing and non-injected cells (n = embryos). (F) At 16–32 cell stages, Phalloidin staining demonstrates that filamentous Actin is apically enriched in Lats2-overexpressing and non-injected cells (n = embryos). (G) At 16–32 cell stages, pERM is localized to the apical membrane in both Lats2-overexpressing and non-injected cells (n = embryos).