Figure 8. Input-output synaptic organization of the larval feeding system and its connectivity architecture in the brain.

Sensory input compartments: Glomerular compartmentalization of the larval antennal lobe (AL) compared to glomerular-like compartmentalization of the subesophageal zone (SEZ). Non-overlapping digital 3D model delineates compartments based on synapse similarity score. Feeding related output compartments: 3D model summarizes the synaptic compartments of median neurosecretory cells (mNSCs), modulatory serotonergic output neurons (Se0) and feeding motor neurons (PMNs, MxN motor and PaN motor). CNS connectivity principle: Different polysynaptic modules are integrated onto existing monosynaptic circuits, or added separately as new multisynaptic circuits, for example the mushroom body module.