Table 1.
Lower limit of detection (LLD) for substances screened in post-mortem whole blood specimens followed by confirmatory lower limit of quantification (LLQ).
| Screening cut offs | Confirmatory cut offs | ||
|---|---|---|---|
| Drug Class | Screening LLD (ng/ml) |
Compounds | Confirmatory LLQ (ng/ml) |
| Alcohola | 0.01% (w/v) | ||
| Ethanola | 0.02% (w/v) | ||
| Amphetamines | 50 | ||
| d-Amphetamine | 20 | ||
| d-Methamphetamine | 50 | ||
| MDMA | 50 | ||
| MDA | 20 | ||
| Phencyclidine (PCP) | 10 | ||
| Phencyclidine | 10 | ||
| Cocaine | 20 | ||
| Cocaine | 50 | ||
| Benzoylecognine | 20 | ||
| Cocaethylene | 20 | ||
| Cannabinoids (THC)b | 5 | ||
| THC-OH | 1 | ||
| Cannabidiol | 1 | ||
| THC-COOH | 5 | ||
| Cannabinol | 1 | ||
| THC | 1 | ||
| Benzodiazepines (Temazepam)b | 20 | ||
| Alprazolam | 5 | ||
| Diazepam | 5 | ||
| Midazolam | 5 | ||
| Nordiazepam | 5 | ||
| Desalkyflurezepam | 5 | ||
| Chlordiazepoxide | 0.05 | ||
| Temazepam | 5 | ||
| Barbiturates (Secobarbital) | 20 | ||
| Phenobarbital | 50 | ||
| Opiates and Opioids | 20 | ||
| Methadone | 50 | ||
| Morphine | 50 | ||
| Fentanyl | 2.5 | ||
| Oxycodone | 50 | ||
| Hydrocodone | 10 | ||
a
Ethanol screened and confirmed by Headspace GC-FID. Values are in percent weight/volume
b
LC-MS/MS technique applied for confirmation. All other confirmatory procedures were done by GC-MS, unless otherwise noted.