Table 2.
Number of Hospitalized Bleeding Events and Bleeding Rates (per Patient-Year) by Site of Bleeding and Cancer Type
| All | Warfarin | LMWH | DOACS | |||||
|---|---|---|---|---|---|---|---|---|
| Count | Rate | Count | Rate | Count | Rate | Count | Rate | |
| All bleeding | 1,204 | 4.41 (4.17–4.67) | 716 | 4.04 (3.75–4.34) | 373 | 5.19 (4.69 −5.74) | 115 | 4.85 (4.02–5.80) |
| Cancer Type | ||||||||
| Lung | 167 | 6.19 (5.30–7.18) | 98 | 6.01 (4.91–7.30) | 58 | 6.72 (5.15–8.63) | 11 | 5.31 (2.79–9.24) |
| Breast | 137 | 2.87 (2.42–3.38) | 91 | 2.78 (2.25–3.40) | 26 | 2.48 (1.66–3.58) | 20 | 4.44 (2.79–6.74) |
| Colorectal | 126 | 4.56 (3.81–5.41) | 78 | 4.33 (3.45–538) | 31 | 4.20 (2.90–5.88) | 17 | 7.59 (4.57–11.90) |
| Upper Gastrointestinal | 56 | 8.64 (6.49–11.14) | 24 | 6.59 (4.32–9.66) | 22 | 9.32 (5.99–13.88) | 10 | 20.83 (10.58–37.14) |
| Prostate | 130 | 3.98 (3.34–4.71) | 99 | 3.86 (3.16–4.68) | 22 | 6.53 (4.20–9.72) | 9 | 2.43 (1.18–4.45) |
| Hematologic | 145 | 3.48 (2.94 −4.08) | 81 | 3.23 (2.58–3.99) | 51 | 3.75 (2.82–4.89) | 13 | 4.32 (2.40–7.20) |
| Other | 462 | 4.94 (4.50–5.40) | 256 | 4.41 (3.89–4.97) | 171 | 6.23 (5.35–7.22) | 35 | 4.34 (3.07–5.97) |
| Bleeding Site | ||||||||
| Intracranial | 136 | 0.51 (0.43–0.60) | 68 | 0.39 (0.31–0.50) | 58 | 0.82 (0.63–1.05) | 10 | 0.43 (0.22–0.76) |
| Gastrointestinal | 740 | 2.74 (2.54–2.94) | 459 | 2.61 (2.38–2.86) | 214 | 3.01 (2.62–3.43) | 67 | 2.84 (2.22–3.59) |
| Other | 328 | 1.23 (1.10–1.36) | 189 | 1.09 (0.94–1.25) | 101 | 1.42 (1.17–1.73) | 38 | 1.62 (1.16–2.20) |