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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: FEBS Lett. 2018 Nov 28;592(23):3819–3834. doi: 10.1002/1873-3468.13251

Figure 1.

Figure 1.

Representation of mouse NOTCH1 extracellular domain depicting EGF repeats with different O-glycan consensus sites that may be modified with the O-glycans shown. One of the EGF domains is magnified to show the consensus site for each type of O-glycan. Different O-glycans, their respective differential extension with sugars (+/−), and the glycosyltransferases responsible for the transfer of each sugar are shown below the diagram. The transfer of O-glucose by POGLUT2 or POGLUT3 occurs only on EGF11 in NOTCH1. The consensus site is between Cys3 and Cys4, indicated by the different location of the glucose symbol in EGF11 in the diagram.