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. Author manuscript; available in PMC: 2019 Dec 6.
Published in final edited form as: Mol Cell. 2018 Oct 11;72(5):849–861.e6. doi: 10.1016/j.molcel.2018.08.044

Figure 3. Single point mutations can alter an isoform’s structural profile.

Figure 3.

DMS reactivity profile comparison of the wild-type SOD1 +71 (SOD +71wt) isoform to two mutants possessing an identical cleavage/polyadenylation site (SOD1 +71A66U, SOD1 +71UGG). Reactivities for each isoform are scaled relative to that isoform’s highest observed reactivity value (100). Top: A comparison of A and C reactivities for SOD +71wt and the single substitution mutant SOD1 +71A66U reveal modest differences in reactivity profiles. Bottom: Extensive differences in reactivity profiles between SOD +71wt and the triple substitution mutant SOD1 +71UGG.