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. Author manuscript; available in PMC: 2019 Dec 6.
Published in final edited form as: Mol Cell. 2018 Oct 11;72(5):849–861.e6. doi: 10.1016/j.molcel.2018.08.044

Figure 6. Relationship of isoform properties with stability.

Figure 6.

(A) A two-part structural motif consisting of a predicted unstructured region (−24 to −18) and a double-stranded region in the poly(A) tail (+8 to +16) correlates with increased isoform stability.

(B) Relationship between half-life, evolutionary conservation and predicted structural character in sequence windows near the poly(A) site. +1 is the first A of the poly(A) tail; −1 is the last nt before the poly(A) tail. Blue bars denote the subset of isoforms with unstructured sequences (≥ 6 predicted unstructured residues) in the indicated sequence window, while red bars denote isoforms in which this sequence is structured (≥ 6 predicted structured residues).