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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: J Am Geriatr Soc. 2018 Oct 5;66(12):2344–2352. doi: 10.1111/jgs.15581

Figure 4.

Figure 4.

Age-Varying Association of non-HDL Cholesterol Levels and Alzheimer’s Disease

aCurves depict hazard ratios (with shading representing 95% confidence intervals) comparing the average non-HDL cholesterol level given on the x-axis to a reference value of 160 mg/dL. Cholesterol level was modeled using natural cubic splines (with knots at 10%, 50%, and 90%-iles of exposure distributions); p-values provided are for joint (omnibus) tests of these spline parameters. Boxplots summarize the distribution of average non-HDL cholesterol levels observed in the sample. Models adjusted for sex, race, education, early life financial difficulty rating, smoking, treatment for hypertension or diabetes, BMI, and stratified by ACT cohort and APOE genotype..