Table 2.
Adjusted mean change (95% CI) in CVD risk and risk factors between enrollment and the second home visit among women premenopausal at enrollment a
| N | 10-year CVD risk (%) | Weight (kg) | BMI (kg/m2) | Waist (cm) | Systolic BP (mmHg) | |
|---|---|---|---|---|---|---|
| All | ||||||
| BC | 296 | 2.7 (2.3, 3.1) | 1.9 (1.0, 2.8) | 0.9 (0.5, 1.2) | 4.5 (3.4, 5.5) | 4.4 (3.0, 5.7) |
| No BC | 394 | 2.8 (2.4, 3.1) | 1.6 (0.8, 2.4) | 0.8 (0.5, 1.0) | 3.7 (2.8, 4.6) | 5.6 (4.4, 6.7) |
| P-value | 0.867 | 0.648 | 0.616 | 0.248 | 0.193 | |
| BMI<25 at enrollment | ||||||
| BC | 142 | 1.8 (1.6, 2.1) | 2.3 (1.5, 3.2) | 0.9 (0.6, 1.3) | 4.9 (3.6, 6.1) | 3.8 (1.9, 5.7) |
| No BC | 193 | 1.8 (1.6, 2.0) | 2.1 (1.4, 2.9) | 0.9 (0.7, 1.2) | 4.0 (3.0, 5.1) | 5.3 (3.7, 7.0) |
| P-value | 0.992 | 0.714 | 0.995 | 0.320 | 0.236 | |
| BMI 25.0–29.9 at enrollment | ||||||
| BC | 86 | 2.7 (2.1, 3.3) | 1.5 (−0.2, 3.1) | 0.7 (0.1, 1.4) | 4.7 (3.0, 6.5) | 4.9 (2.4, 7.3) |
| No BC | 103 | 2.6 (2.1, 3.2) | 2.5 (1.0, 4.0) | 1.0 (0.5, 1.6) | 4.1 (2.5, 5.6) | 5.5 (3.3, 7.7) |
| P-value | 0.807 | 0.361 | 0.500 | 0.577 | 0.690 | |
| BMI 30+ at enrollment | ||||||
| BC | 68 | 4.6 (3.2, 6.0) | 1.4 (−1.4, 4.3) | 0.8 (−0.2, 1.9) | 3.7 (1.0, 6.4) | 5.0 (2.0, 8.0) |
| No BC | 98 | 4.9 (3.8, 6.1) | −0.3 (−2.7, 2.0) | 0.2 (−0.7, 1.0) | 2.2 (−0.0, 4.5) | 5.9 (3.5, 8.3) |
| P-value | 0.714 | 0.361 | 0.325 | 0.429 | 0.661 | |
| Premenopausal at enrollment and second visit | ||||||
| BC | 52 | 1.8 (1.3, 2.3) | 1.8 (−0.2, 3.8) | 0.7 (−0.1, 1.4) | 3.6 (1.0, 6.2) | 5.2 (2.4, 8.0) |
| No BC | 142 | 1.9 (1.6, 2.2) | 3.0 (1.7, 4.2) | 1.2 (0.7, 1.6) | 4.2 (2.6, 5.7) | 4.8 (3.1, 6.4) |
| P-value | 0.596 | 0.334 | 0.245 | 0.710 | 0.791 | |
| Premenopausal at enrollment and postmenopausal at second visit | ||||||
| BC | 243 | 3.1 (2.6, 3.6) | 1.7 (0.7, 2.8) | 0.9 (0.5, 1.2) | 4.7 (3.6, 5.8) | 4.3 (2.7, 5.8) |
| No BC | 249 | 3.1 (2.6, 3.6) | 1.0 (0.0, 2.0) | 0.6 (0.2, 0.9) | 3.4 (2.3, 4.5) | 6.0 (4.4, 7.5) |
| P-value | 0.952 | 0.298 | 0.276 | 0.097 | 0.129 | |
| Premenopausal at diagnosis | ||||||
| BC | 187 | 2.4 (2.0, 2.9) | 2.0 (0.8, 3.1) | 0.8 (0.4, 1.3) | 4.5 (3.1, 5.8) | 4.3 (2.5, 6.0) |
| No BC | 394 | 2.6 (2.3, 2.9) | 1.7 (1.0, 2.5) | 0.8 (0.5, 1.1) | 3.7 (2.8, 4.6) | 5.6 (4.4, 6.7) |
| P-value | 0.484 | 0.725 | 0.842 | 0.375 | 0.212 | |
| Postmenopausal at diagnosis | ||||||
| BC | 108 | 3.1 (2.4, 3.8) | 2.1 (0.4, 3.7) | 1.0 (0.4, 1.6) | 4.8 (3.0, 6.7) | 4.7 (2.3, 7.0) |
| No BC | 394 | 2.9 (2.5, 3.2) | 1.4 (0.6, 2.2) | 0.7 (0.4, 1.0) | 3.4 (2.5, 4.3) | 5.3 (4.1, 6.5) |
| P-value | 0.591 | 0.492 | 0.313 | 0.195 | 0.643 | |
| Chemotherapy, no endocrine therapy | ||||||
| BC | 37 | 2.0 (1.0, 3.1) | 1.1 (−1.5, 3.7) | 0.7 (−0.2, 1.7) | 4.5 (1.6, 7.5) | 2.5 (−1.4, 6.3) |
| No BC | 394 | 2.7 (2.4, 3.0) | 1.6 (0.8, 2.4) | 0.8 (0.5, 1.0) | 3.6 (2.7, 4.5) | 5.3 (4.2, 6.5) |
| P-value | 0.241 | 0.711 | 0.961 | 0.542 | 0.161 | |
| Endocrine therapy, no chemotherapy | ||||||
| BC | 120 | 2.5 (1.9, 3.1) | 2.4 (0.9, 3.9) | 1.0 (0.5, 1.6) | 4.8 (3.1, 6.4) | 3.6 (1.5, 5.8) |
| No BC | 394 | 2.7 (2.4, 3.0) | 1.6 (0.8, 2.4) | 0.8 (0.5, 1.1) | 3.6 (2.7, 4.5) | 5.5 (4.3, 6.7) |
| P-value | 0.517 | 0.350 | 0.435 | 0.239 | 0.135 | |
| Chemotherapy and endocrine therapy | ||||||
| BC | 88 | 3.0 (2.3, 3.7) | 1.5 (−0.2, 3.2) | 0.7 (0.1, 1.3) | 4.7 (2.7, 6.6) | 5.6 (3.1, 8.1) |
| No BC | 394 | 2.7 (2.4, 3.1) | 1.6 (0.8, 2.4) | 0.7 (0.5, 1.0) | 3.5 (2.6, 4.4) | 5.4 (4.3, 6.6) |
| P-value | 0.548 | 0.957 | 0.918 | 0.297 | 0.918 | |
Abbreviations: CVD, cardiovascular disease; BC, breast cancer
a
Adjusted for age at enrollment, time between enrollment and second visit, and enrollment measure