Table 3.

Fold-change in gene expression in HSV-2 infected foreskin compared to uninfected foreskins.

Gene	> 10³ HSV gD transcripts^a	< 5×10² HSV gD transcripts	Day 20
CCL2/MCP-1	8.80	−8.65	1.55
CCL5/RANTES	65.33	2.31	6.52*
CCL7/MCP-3	5.67	−1.44	1.40
CD4	5.22	1.10	2.66
CD8 alpha	4.36	−1.26	3.17
CD14	1.66	−2.22	1.73
CD25	2.13	−1.16	1.56
CD28	3.56	−1.47	1.68
CD39	−1.21	−2.78	1.49
CD40	1.63	1.03	1.99
CD62L	−2.43*	−2.73	−1.65
CD72	8.82	−3.15	8.77
CD94	10.26	1.49	7.30
CD96	118.12	31.71	51.97
CD103	−1.12	1.15	1.48
CD134	−1.42	−1.55	−1.24
CD152/CTLA-4	49.12	−17.78	−1.13
CXCL10	107.59	30.39	6.91*
CXCL11	354.47	21.16*	17.89*
CXCL12	2.54	1.27	1.67
IFNβ	−1.49	−2.20	−26.73
IFN γ	134.01	4.14	12.49
IFNAR1	−1.19	−2.06	1.36
IFNAR2	1.62	−1.50	1.39
IFNGR1	1.07	−1.40	1.14
IL-1b	1.85	1.71	−1.02
IL-2	1.28	−4.91	2.89
IL-4	−1.24	−1.81	1.14
IL-7	4.25	1.90	4.34*
IL-10	2.81	−7.14	1.62
IL-12 p35	1.01	−5.13	1.22
IL-12 p40	−1.41	−10.06	1.49
IL-15	2.27	−3.00	2.04
IL-17A	1.02	−1.07	1.14
IL-21	3.00	−1.38	4.28
IL-27	1.87	−1.19	1.88
IL-33	1.81	1.31	4.86*
KLRG1	−1.29	−3.22	1.57
PRF-1	9.03	−1.39	2.70
TGFβ	−1.08	−2.52	−1.12
TNFα	−1.40	−1.74	−1.53

Biopsies from lesion days 1 and 4 were segregated for analysis according to the number of HSV gD transcripts present (> 10³ HSV gD (n=3) or < 5×10² HSV gD (n=4). Fold-change values marked with an asterisk reached statistical significance compared to gene expression in uninfected foreskin (p<0.05, Student’s t test).