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. Author manuscript; available in PMC: 2019 Jun 3.
Published in final edited form as: Nat Chem Biol. 2018 Dec 3;15(1):11–17. doi: 10.1038/s41589-018-0160-y

Figure 1|. Overall structure of EP3 receptor bound to misoprostol-FA.

Figure 1|

(a) EP3 receptor viewed parallel to the plasma membrane, and (b) from the extracellular side looking down into the misoprostol-FA binding pocket. Misoprostol-FA (green carbon) is shown as sticks. Disordered parts of loops are represented as dashed lines. ECL2 is shown in red. The canonical ‘toggle-switch’ Trp2956.48 is shown with cyan atom spheres for reference.