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. Author manuscript; available in PMC: 2019 Jun 3.
Published in final edited form as: Nat Chem Biol. 2018 Dec 3;15(1):11–17. doi: 10.1038/s41589-018-0160-y

Figure 4|. Docking of small agonists on the EP3 receptor.

Figure 4|

(a) Misoprostol-FA in the EP3-miso structure. (b-d) Docking of the indicated agonists on EP3-miso crystal structure. EP3 receptor is show as cartoon except helix VII shown as ribbon. Misoprostol-FA and modelled agonists are in green and magenta sticks, respectively. Water and Gly1413.36 are shown as red and gold spheres, respectively. Dotted lines represent polar interactions. (e) Sequence alignment of the EP3 receptor binding pocket with other lipid receptors.