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. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Neuroimage. 2018 Oct 6;185:181–190. doi: 10.1016/j.neuroimage.2018.10.002

Figure 2.

Figure 2.

Simulated basis functions of the Hadamard combinations for the eight coupled metabolites edited in the HERCULES experiment. Note the segregation of overlapping signals (e.g., GSH and GABA around 3 ppm) into orthogonal difference spectra (GSH in A-B+C-D, GABA in A+B-C-D), and the differentiation of the NAA- and NAAG-aspartyl singles at 2.6 ppm in the A-B+C-D spectrum. The signal intensities represent equimolar concentrations.