Table IV.

Axitinib pharmacokinetic (PK) parameters (median (range))

Pharmacokinetic Parameter	Dose Level 2.4 mg/m2		Dose Level 3.2 mg/m2
	Day 1 (n=12)	Day 8 (n=12)	Day 1 (n=6)	Day 8 (n=5)
Tmax (h)	2.0 (1.0–4.0)	1.5 (0–4.0)	2.0 (1.0–4.0)	2.0 (1.1–4.0)
Cmax (ng/mL)	23.8 (2.5–55.6)	47.4 (4.5–92.6)	38.0 (16.3–58.1)	41.5 (15.5–76.5)
Half life (h)	2.2 (0.7–5.2)	2.5 (0.9–631.5)	2.6 (1.1–3.2)	1.8 (1.1–4.3)
AUC0–8h (h•ng/mL)	91.0 (10.7–264.1)	146.7 (8.9–372.7)	134.3 (59.0–236.0)	139.9 (54.9–349.1)
Accumulation (AUC Day8/Day1)		1.7 (0.3–4.7)		1.8 (0.4–2.5)
Cl/F (L/h)	28.0 (9.8–230.1)		32.6 (14.2–65.2)
Cl/m2 (L/h/m2)	21.4 (6.0–230.1)		19.9 (11.4–61.5)
V/F (L)	74.9 (43.6–888.7)		99.4 (48.9–150.6)
V/m2 (L/m2)	67.4 (39.1–888.7)		65.5 (39.1–101.6)