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Super TOPFLASH luciferase reporter assay for canonical WNT signaling for the identified WNT1 mutation - The expression of mutant WNT1 (c.1051T>C) could not induce canonical WNT signaling compared to the wild-type WNT1 in the Super TOPFLASH luciferase reporter assay. Co-expressing wild-type and mutated WNT1 (c.1051T>C) did not reduce the induced luciferase activity by wild-type WNT1. *** p<0.0005, error bars represent S.D., N=3.
