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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Dev Biol. 2018 Nov 8;445(1):90–102. doi: 10.1016/j.ydbio.2018.11.001

Figure 4. Mitochondrial Loss and Respiration Defects in Pitx2MCK Muscle.

Figure 4.

(A, D) Transmission electron microscopy for TA at P30 indicated distorted and smaller sarcomeres. Z, I, and M bands show differences. Mitochondria (M) and sarcoplasmic reticulum (SR) are vestigial. (E-H) Seahorse assay on primary TA muscle cell cultures (E, F) from WT and Pitx2MCK mice (n=3). (G) OCR and (H) ECAR measure mitochondrial respiration and glycolysis, respectively.