Table 3.

Functional connectome studies of aberrant connectivity

Author	Age	Sample Size	Finding
Smyser et al., 2013	Infants	25 preterm, 14 preterm+PHI, 25 TC	Reduced fc in PHI compared to preterm without injury and TC, with reduced fc more prominent in injured hemisphere
He et al., 2015	Infants	27 preterm+DWMA	Reduced within-network fc in infants with moderate-severe DWMA compared to mild DWMA
Arichi et al., 2014	Infants	3 preterm, 3 preterm+PHI	Reduced diffusion and functional connectivity between motor and supplementary motor
Cai et al., 2017	Infants	40 preterm, 22 preterm+PVL, 31 TC	Alterations in thalamus-salience network connectivity in PVL
Burton et al., 2009	Children-adults	12 preterm+SDCP, 11 TC	Aberrant motor network connectivity in SDCP
Lee et al., 2011	Children-adults	43 preterm+PVL+SDCP, 20 TC	Reduced motor network connectivity in PVL+SDCP
Lee et al., 2017	Children-adults	14 preterm+PVL+SDCP, 20 TC	Reduced motor network efficiency in PVL+SDCP
Wingert et al., 2010	Children-adults	10 SDCP, 10 TC	Reduced cortical activation to sensory task in SDCP
Froudist-Walsh et al., 2015	Adults	21 preterm, 20 preterm+IVH±PHVD, 46 TC	Altered cortical activation during working memory task in IVH±PHVD
Kalpakidou et al., 2014	Adults	13 preterm, 17 preterm+IVH, 12 preterm+PHVD, 17 TC	Reduced cortical activation during working memory task in PHVD compared to IVH alone
Tusor et al., 2014	Infants	15 term+HIE, 23 TC	RSNs unilateral with reduced long-distance connections in HIE
Chalia et al., 2016	Infants	6 HIE	Changes in blood oxygenation related to EEG burst activity in HIE as measured with DOT
Hebden et al., 2002	Infants	1 HIE	Blood volume and oxygen saturation reduced in infant with IVH as measured with DOT
Singh et al., 2014	Infants	1 HIE	Decreased cortical blood volume following seizure as measured with DOT
White et al., 2012	Infants	3 preterm, 1 preterm+IVH, 1 preterm+stroke, 3 TC	Absent bilateral connectivity in injured hemisphere in preterm infant with occipital stroke as measured with DOT
Austin et al., 2006	Infants	1 preterm+IVH, 5 preterm	Lower oxygenation in IVH as measured with DOT
Gibson et al., 2006	Infants	2 preterm+IVH, 4 preterm	Reduced total hemoglobin changes from passive arm movements in IVH as measured with DOT
Omidvarnia et al., 2015	Infants	6 preterm+IVH, 11 preterm	Reduced electrical coherence in long-range connections in IVH; greater network vulnerability in infancy associated with poorer neurodevelopmental outcome as measured with EEG

fc, functional connectivity; TC, term-born control; PHI, periventricular hemorrhagic infarction; DWMA, diffuse white matter abnormality; SDCP, spastic diplegic cerebral palsy; PVL, periventricular leukomalacia; IVH, intraventricular hemorrhage; PHVD, post-hemorrhagic ventricular dilatation; RSN, resting state network; HIE, hypoxic ischemic encephalopathy; DOT, diffuse optical tomography; EEG, electroencephalogram