Table 2. Coordinates of significant brain areas where resting-state functional connectivity with left motor cortex were significantly related with cortical inhibition and overall symptoms in schizophrenia spectrum disorder patients.
Talairach (x, y, z) mm |
Brodmann area |
Cluster size |
r | |
---|---|---|---|---|
SICI related rsFC in schizophrenia | ||||
Left middle prefrontal gyrus | (–25, 47, –2) | 10/11 | 206 | −0.81* |
Left middle Cerebellum (VIII) | (–15, –66, –34) | n/a | 222 | -0.75* |
Right middle prefrontal gyrus | (39, 39, –6) | 10/11 | 427 | -0.87* |
Right Insula | (46, 9, –5) | 13 | 219 | -0.77* |
BPRS related rsFC in schizophrenia | ||||
Left superior occipital gyrus | (–17, –85, 41) | 19 | 656 | 0.79* |
Left postcentral gyrus | (–35, –29, 47) | 3/4 | 601 | 0.83* |
Left middle prefrontal gyrus | (–20, 54, –4) | 10/11 | 546 | -0.84* |
Left precentral gyrus | (–30, –14, 60) | 4/6 | 256 | 0.73* |
Left middle occipital gyrus | (–18, –97, 9) | 18 | 246 | 0.78* |
Left inferior frontal gyrus | (–50, 6, 24) | 9/44 | 210 | 0.73* |
Left cerebellum (VI) | (–30, –43, –27) | n/a | 204 | -0.81* |
Right superior occipital gyrus | (19, –86, 33) | 7/19 | 808 | 0.74* |
Right superior parietal lobule | (28, –65, 52) | 7 | 754 | 0.81* |
Right postcentral gyrus | (33, –30, 48) | 3/4 | 535 | 0.86* |
Right anterior cingulate | (10, 36, 25) | 32 | 358 | -0.83* |
Right cerebellum (VI) | (22, –76, –12) | n/a | 328 | 0.75* |
Right precentral gyrus | (40, –18, 60) | 4/6 | 251 | 0.81* |
r: correlation coefficients between behavioral, i.e., Brief Psychiatric Rating Scale total score (BPRS) and short-interval intracortical inhibition (SICI), and the mean resting-state functional connectivities (rsFCs) between motor cortex and each cluster.
corrected p<0.05. Data for healthy controls are in Supplementary Table S1.