Figure 3.
Hub distribution of the neonate connectome and higher developmental rates in hub regions compared to non-hubs. (A) A 3D representation of the hub distribution of the neonate structural connectome with the hub nodes in red and non-hub nodes in gray overlaid on the group-averaged backbone network. Cluster-1 nodes identified by a data-driven clustering analysis were marked with blue circle. Of note, all cluster-1 nodes were hub regions of the connectome. (B) Scatter plot showing more rapid age-related increases of nodal efficiency (Enodal) in hub regions than non-hub regions. Partial correlation between age and regional efficiency were fitted separately in all hub regions (red dots) and non-hub regions (gray dots). Interaction effect between age and hub category was significant (p <10−3). (C) Scatter plot showing significant linear correlation between nodal efficiency and developmental rate (of nodal efficiency) across the brain regions. In (C), each dot represents one of the 34 brain regions with significant nodal efficiency increases, with the hub/non-hub regions represented by red/gray dots. See the legend of Figure 2 for abbreviations of brain regions.