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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Anat Rec (Hoboken). 2018 Nov 1;301(12):1999–2013. doi: 10.1002/ar.23959

Figure 1:

Figure 1:

Nucleo-cytoplasmic shuttling of actin and types of nuclear actin. Importin 9 (blue) takes actin (red) and Cofilin (orange) complexes into the nucleus through the nuclear pore complex (NPC). Exportin 6 (purple) mediates the nuclear export of actin and Profilin (green) complexes. Within the nucleus actin takes on many forms. Actin can polymerize into weakly phalloidin-stainable rods and Cofilin-decorated rods. For simplicity, individual actin filaments are shown to represent nuclear actin rods, but rods may be composed of bundles of actin filaments. Additionally, there are short polymers of actin and pools of actin monomers that exist on their own, in an altered conformational state (dark green circle on actin) or complexed with Cofilin or Profilin.