Table 3.
Genotype and allele frequencies for the GRP78 promoter polymorphism between asthenozoospermia and controls
| Genotype/allele | Asthenozoospermic group (%) | Control group (%) | OR (95% CI)* | P value* |
|---|---|---|---|---|
| rs3216733 | ||||
| dd | 152 (38.0) | 186 (46.5) | 1.00 | |
| Gd | 199 (49.8) | 175 (43.7) | 1.42 (1.06–1.93) | 0.020 |
| GG | 49 (12.2) | 39 (9.8) | 1.45 (0.91–2.35) | 0.120 |
| Gd/GG | 248 (62.0) | 214 (53.5) | 1.43 (1.08–1.91) | 0.013 |
| d | 503 (62.9) | 547 (68.4) | 1.00 | |
| G | 297 (37.1) | 253 (31.6) | 1.26 (1.03–1.56) | 0.027 |
| rs17840761 | ||||
| CC | 112 (28.0) | 109 (27.3) | 1.00 | |
| CT | 190 (47.5) | 181 (45.2) | 1.05 (0.75–1.46) | 0.797 |
| TT | 98 (24.5) | 110 (27.5) | 0.86 (0.59–1.27) | 0.447 |
| CT/TT | 288 (72.0) | 291 (72.7) | 0.98 (0.71–1.34) | 0.880 |
| C | 414 (51.8) | 399 (49.9) | 1.00 | |
| T | 386 (48.2) | 401 (50.1) | 0.93 (0.76–1.13) | 0.443 |
| rs17840762 | ||||
| C/C | 300 (75.0) | 297 (74.3) | 1.00 | |
| C/T | 94 (23.5) | 92 (23.0) | 1.03 (0.74–1.44) | 0.864 |
| T/T | 6 (1.5) | 11 (2.7) | 0.51 (0.19–1.41) | 0.195 |
| CT/TT | 100 (25.0) | 103 (25.7) | 0.97 (0.70–1.34) | 0.866 |
| C | 394 (86.8) | 686 (85.7) | 1.00 | |
| T | 106 (13.2) | 114 (14.3) | 0.92 (0.69–1.23) | 0.583 |
SNPs single nucleotide polymorphisms, d deleted, OR odds ratio, CI confidence interval, dd deletion
*Adjusted for age, sex, smoking, drinking, and sleeping statuses by the logistic regression model